Biomedical and Pharmacology JournalVol. 7 No. 2

A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets

Ghassan F. Shattat

College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Received on October 30, 2014 and accepted on December 11, 2014

DOI: http://dx.doi.org/10.13005/bpj/504

ABSTRACT

Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including very low-density lipoprotein and low-density lipoprotein along with reduced high-density lipoprotein levels. This elevation of plasma lipids is among the leading risk factors associated with cardiovascular diseases. In the meantime, statins and fibrates remain the major anti-hyperlipidemic agents for the treatment of elevated plasma cholesterol and triglycerides respectively, with the price of severe side effects on the muscles and the liver. The present review focuses mainly on the types of hyperlipidemias, lipid metabolism, treatments and new drug targets for the treatment of elevated lipid profile. Many agents such as lanosterol synthase inhibitors, squalene epoxidase inhibitors, diacyl glycerol acyl transferase inhibitors, ATP citrate lyase inhibitors have shown a promising potential in the treatment of hyperlipidemia in clinical trials.

Keywords : Hyperlipidemia, Lipid metabolism, Hypolipidemic drugs, Squalene epoxidase inhibitors, Lanosterol synthase inhibitors, Diacyl glycerol acyl transferase inhibitors.

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